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97\u5dfb5\u53f7\u63b2\u8f09<\/div>"},"content":{"rendered":"\n
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\u4eca\u304b\u3089\u7d041\u4e16\u7d00\u3082\u6614\u306e\u67ff\u5185\u5148\u751f\u306e\u5fa1\u7814\u7a76\u306e\u771f\u4fa1\u306f\u9577\u671f\u9593\u3092\u7d4c\u3066\u5b9a\u7740\u3059\u308b\u306e\u3067\u30595\uff09<\/sup>\u3002\u67ff\u5185\u5148\u751f\u306e\u884c\u3063\u305f\u3001\u819c\u69cb\u9020\u3092\u6301\u3063\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u547c\u5438\u304c\u542b\u6c34\u30a2\u30bb\u30c8\u30f3\u62bd\u51fa\u3067\u30ea\u30f3\u8102\u8cea\u3092\u9664\u304f\u3068\u505c\u6b62\u3057\u3001\u30ea\u30f3\u8102\u8cea\u3092\u518d\u6dfb\u52a0\u3059\u308b\u3068\u56de\u5fa9\u3059\u308b\u3068\u3044\u3046\u518d\u69cb\u6210\u5b9f\u9a137\uff09<\/sup>\u306f\u753b\u671f\u7684\u3067\u3001\u305d\u306e\u5f8c\u306bS. Fleisher\u306b\u3088\u3063\u3066\u4e16\u754c\u7684\u306a\u6a19\u6e96\u6cd5\u3068\u306a\u308a\u307e\u3057\u305f8\uff09<\/sup>\u3002\u5f53\u6642\u3001\u9175\u7d20\u5b66\u306b\u53d6\u308a\u3064\u304b\u308c\u3066\u3044\u305f\u4e16\u754c\u4e2d\u306e\u7814\u7a76\u8005\u3089\u304c\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u306e\u4e2d\u9593\u5316\u5408\u7269\u306e\u5b9f\u8a3c\u306b\u5931\u6557\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3053\u3067P. Mitchell\u535a\u58eb\u306f\u306a\u305c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u819c\u69cb\u9020\u306a\u306e\u304b\u3092\u8003\u3048\u3001\u751f\u4f53\u819c\u5185\u5916\u306e\u96fb\u6c17\u5316\u5b66\u30dd\u30c6\u30f3\u30b7\u30e3\u30eb\u5dee<\/a>\u304c\u4eee\u60f3\u306eATP\u5408\u6210\u9175\u7d20\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u4f1d\u3048\u3066ATP\u3092\u5408\u6210\u3059\u308b\u3068\u3044\u3046\u5316\u5b66\u6d78\u900f\u5727\u8aac\u30921961\u5e74\u306b\u63d0\u5531\u3057\u305f\u306e\u3067\u30599\uff09<\/sup>\u3002\u305d\u306e\u5f8c\u3001\u7b46\u8005\u306fATP\u5408\u6210\u9175\u7d20\u3092\u30ea\u30f3\u8102\u8cea\u5c0f\u80de\u306b\u7d44\u8fbc\u3080\u30b3\u30fc\u30eb\u9178\u900f\u6790\u5c0f\u80de\u518d\u69cb\u6210\u6cd5\u306b\u6210\u529f\u3057\u3001\u9042\u306b\u5316\u5b66\u6d78\u900f\u5727\u8aac\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f10, 11\uff09<\/sup>\u3002\u3053\u306e\u6210\u529f\u3067Mitchell\u535a\u58eb\u306b\u30ce\u30fc\u30d9\u30eb\u8cde\u304c\u6388\u4e0e\u3055\u308c\u3001\u7fcc\u5e74\u306e1979\u5e74\u306e\u30ab\u30ca\u30c0\u3067\u306e\u7b2c11\u56de\u56fd\u969b\u751f\u5316\u5b66\u4f1a\u8b70\u306e\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0Bioenergetics and Transport\u3067\u3001Mitchell\u535a\u58eb\u306b\u7d9a\u304d\u79c1\u304c\u819c\u69cb\u9020\u306e\u518d\u69cb\u6210\u306b\u3088\u308b\u819c\u306e\u6c34\u7d20\u30a4\u30aa\u30f3\u8f38\u9001\u3068\u4e2d\u6838\u306eATP\u5408\u6210\u9175\u7d20\u306e\u7d50\u6676\u5316\u3092\u5831\u544a\u3057\u307e\u3057\u305f\uff08\u56f32\uff0910, 11\uff09<\/sup>\u3002\u67ff\u5185\u5148\u751f\u306e\u5148\u99c6\u7684\u7814\u7a76\u304c\u6700\u3082\u8f1d\u3044\u305f\u77ac\u9593\u3067\u3057\u305f\u3002\u81ea\u5b85\u3067\u5b9f\u9a13\u3055\u308c\u3066\u3044\u305fMitchell\u535a\u58eb\u3092\u81ea\u6cbb\u533b\u5927\u5ba2\u54e1\u6559\u6388\u306b\u304a\u8fce\u3048\u3057\u3066\u7814\u7a76\u3092\u7d9a\u3051\u307e\u3057\u305f\uff08\u56f33\uff09\u3002\u3055\u3089\u306b\u7b2c12\u56de\u56fd\u969b\u751f\u5316\u5b66\u4f1a\u8b70\u3067\u306f\u819c\u96fb\u4f4d\u3067ATP\u5408\u6210\u3092\u8a3c\u660e\u3057\u3066\u65b0\u5b66\u8aac\u3092\u6c7a\u5b9a\u7684\u306a\u3082\u306e\u3068\u3057\u305f\u306e\u3067\u305911\uff09<\/sup>\u3002<\/strong>ATP\u5408\u6210\u9175\u7d20\u306eFo\u3068\u3088\u3070\u308c\u308b\u819c\u5185\u90e8\u5206\u306f\u6c34\u7d20\u30a4\u30aa\u30f3\u304c\u96fb\u6c17\u5316\u5b66\u30dd\u30c6\u30f3\u30b7\u30e3\u30eb\u5dee\u3067\u99c6\u52d5\u3055\u308c\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u3067\u56de\u8ee2\u3059\u308b\u30e2\u30fc\u30bf\u30fc\u3067\u3042\u308a\u3001\u305d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u304cATP\u5408\u6210\u9175\u7d20\u306e\u9ad8\u6b21\u69cb\u9020\u306e\u5909\u5316\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u306a\u3063\u3066\u3001ADP\uff0bPi\u304b\u3089ATP\u3092\u5408\u6210\u3059\u308b\u3068\u3044\u3046\u6a5f\u5e8f\u304c\u78ba\u7acb\u3057\u307e\u3057\u305f\uff08\u56f34\uff0912\uff09<\/sup>\u3002\u305d\u306e\u529f\u7e3e\u3067\u30ce\u30fc\u30d9\u30eb\u8cde\u3092\u5f97\u305fJ. Walker\u535a\u58eb\u3068\u7b46\u8005\u306e\u5171\u8ad6\u6587\u3082\u300c\u751f\u5316\u5b66\u300d\u3092\u901a\u3057\u3066\u56fd\u5185\u306b\u5e83\u304f\u4f1d\u3048\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

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\u7814\u7a76\u8005\u306e\u5ba2\u89b3\u7684\u8a55\u4fa1<\/strong><\/strong><\/h3>\n\n\n\n

\u57fa\u790e\u751f\u547d\u79d1\u5b66\u306e\u56fd\u969b\u7684\u8a55\u4fa1\u3068\u306a\u308b\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u306e\u53d7\u8cde\u8005\u3092\u80b2\u3066\u305f\u751f\u5316\u5b66\u4f1a\u306e\u57fa\u76e4\u306f\u300c\u751f\u5316\u5b66\u300d\u3067\u57f9\u308f\u308c\u307e\u3057\u305f\u3002\u5353\u8d8a\u3057\u305f\u7814\u7a76\u8005\u3092\u8a55\u4fa1\u3059\u308b\u306b\u306f\u5ba2\u89b3\u6027\u304c\u5fc5\u8981\u3067\u3059\u3002\u6b8b\u5ff5\u306a\u304c\u3089\u3001\u65e5\u672c\u3067\u306e\u7814\u7a76\u8005\u306e\u8a55\u4fa1\u306f\u3001\u9650\u3089\u308c\u305f\u7533\u8acb\u8005\u3092\u6709\u540d\u5927\u5b66\u306e\u59d4\u54e1\u4f1a\u304c\u9078\u3076\u5b66\u4f1a\u8cde\u3084\u79d1\u7814\u8cbb\u63a1\u629e\u304c\u4e2d\u5fc3\u3067\u3059\u3002\u3057\u304b\u3057\u30011993\u5e74\u306bScience<\/em>\u8a8c\u304c\u65e5\u672c\u306e\u5927\u5b66\u306e\u57fa\u790e\u751f\u7269\u5b66\u3092\u8a55\u4fa1\u3057\u3001\u7121\u540d\u306e\u81ea\u6cbb\u533b\u5927\u304cimpact factor\u3067\u6771\u5927\u3001\u4eac\u5927\u3092\u8d85\u3048\u3066\u3001\u962a\u5927\u3001\u795e\u6238\u5927\u306b\u6b21\u30503\u4f4d\u3067\u3042\u308b\u3053\u3068\u304c\u300c\u751f\u5316\u5b66\u300d\u306b\u7d39\u4ecb\u3055\u308c\u885d\u6483\u3092\u4e0e\u3048\u307e\u3057\u305f13\uff09<\/sup>\u30021\u4eba\u306e\u79d1\u5b66\u8005\u306e\u5168\u8ad6\u6587\u3092\u88ab\u5f15\u7528\u6570\u306f\u3058\u3081\u5ba2\u89b3\u7684\u306a\u6307\u6a19\u3067\u8a55\u4fa1\u3059\u308bScholarGPS\uff08\u79d1\u5b66\u8005\u6e2c\u4f4d\u6a5f\u69cb\uff09\u304c\u4e16\u754c\u3067\u306f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5ea6ScholarGPS\u304b\u3089\u7b46\u8005\u306f2024\u5e74\u5ea6\u306eTop Scholar\uff08\u4e0a\u4f4d0.5%\uff09\u3068\u3057\u3066\u304a\u795d\u3044\u3092\u9802\u304d\u307e\u3057\u305f\u3002\u5168\u79d1\u5b66\u8005\u306e0.5\uff05\u306f\u5396\u5927\u3067\u3059\u304c\u3001\u5c02\u9580\u9818\u57df\u306e\u6804\u990a\u79d1\u5b66\u306b\u9650\u308b\u3068\u65e5\u672c\u3067\u306f14\u540d\u3067\u30011\u4f4d\u306f\u6771\u5927\u306e\u9580\u8107\u5b5d\u5148\u751f\u3001\u79c1\u306f4\u4f4d\u3067\u3059\u3002\u540c\u6a5f\u69cb\u3067\u306f\u79c1\u306e\u5168\u8ad6\u6587369\u7de8\u309215\u5206\u91ce\u5225\u306b\u6709\u52b9\u6027\u3001\u5f71\u97ff\u529b\u3001\u8cea\u3001\u9806\u4f4d\u3067\u4eba\u5de5\u77e5\u80fd\u3092\u4f7f\u3063\u3066\u63a1\u70b9\u3059\u308b\u306e\u3067\u3059\u3002\u7121\u540d\u306e\u5973\u5b50\u6804\u990a\u5927\u5b66\u3067\u3082\u300c\u751f\u5316\u5b66\u300d\u306b\u767a\u8868\u305714\uff09<\/sup>\u3001\u77e5\u540d\u5ea6\u3068\u95a2\u4fc2\u306a\u304f\u8a55\u4fa1\u3055\u308c\u308b\u70b9\u304c\u5927\u4e8b\u3067\u3059\u3002<\/p>\n\n\n\n

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\u4eca\u5f8c\u306e\u300c\u751f\u5316\u5b66\u300d\u8a8c\u306e\u767a\u5c55\u3092\u7948\u3063\u3066<\/strong><\/strong><\/strong><\/h3>\n\n\n\n

\u300c\u751f\u5316\u5b66\u300d\u8a8c\u306f\u65e5\u672c\u8a9e\u306a\u306e\u3067\u56fd\u5185\u306e\u7814\u7a76\u8005\u306b\u3068\u3063\u3066\u8aad\u307f\u6613\u3044\u3068\u3044\u3046\u5229\u70b9\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u60c5\u5831\u4f1d\u9054\u624b\u6bb5\u306e\u767a\u9054\u306b\u3088\u3063\u3066\u3001\u7d19\u5a92\u4f53\u306e\u300c\u86cb\u767d\u8cea \u6838\u9178 \u9175\u7d20\u300d\u3084\u300c\u7d30\u80de\u5de5\u5b66\u300d\u7b49\u306e\u751f\u5316\u5b66\u60c5\u5831\u8a8c\u306f\u6b21\u3005\u3068\u59ff\u3092\u6d88\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u4e00\u65b9\u3067\u3001\u300c\u751f\u5316\u5b66\u300d\u8a8c\u306e\u3088\u3046\u306a\u548c\u6587\u8a8c\u306f\u3001\u5192\u982d\u306b\u8ff0\u3079\u305f\u3088\u3046\u306bGoogle Scholar\u7b49\u3067\u4e16\u754c\u306e\u7814\u7a76\u8005\u304c\u8aad\u3081\u308b\u306e\u3067\u3059\u3002Mitchell\u535a\u58eb\u3082\u79c1\u3082\u5ba2\u89b3\u7684\u8a55\u4fa1\u306e\u5fa1\u852d\u3067Gordon\u79d1\u5b66\u4f1a\u8b70\u306b\u62db\u5f85\u3055\u308c\u6bce\u5e741\u9031\u9593\u3001\u8a0e\u8b70\u3067\u304d\u307e\u3057\u305f\u3002\u300c\u751f\u5316\u5b66\u300d\u8a8c\u306f\u3001\u3053\u306e\u3088\u3046\u306b\u65e5\u672c\u306e\u751f\u5316\u5b66\u8005\u306f\u52ff\u8ad6\u306e\u3053\u3068\u3001\u751f\u547d\u79d1\u5b66\u306b\u95a2\u9023\u3059\u308b\u5404\u9818\u57df\u306e\u7814\u7a76\u3068\u6559\u80b2\u306b\u8ca2\u732e\u3057\u3001\u3055\u3089\u306b\u60c5\u5831\u79d1\u5b66\u306e\u767a\u5c55\u3067\u4e16\u754c\u306e\u7814\u7a76\u8005\u306b\u3082\u5bc4\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u751f\u5316\u5b66\u4f1a\u306e\u5f79\u54e1\u3068\u3057\u3066\u3001\u307e\u305f\u7814\u7a76\u8005\u3068\u3057\u3066\u300c\u751f\u5316\u5b66\u300d\u3092\u6d3b\u7528\u3057\u3066\u304d\u305f\u7b46\u8005\u3068\u3057\u3066\u3001\u4eca\u5f8c\u306e\u672c\u8a8c\u306e\u767a\u5c55\u3092\u7948\u3063\u3066\u7b46\u3092\u64f1\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\uff08\u81ea\u6cbb\u533b\u79d1\u5927\u5b66\u540d\u8a89\u6559\u6388\uff0c\u5973\u5b50\u6804\u990a\u5927\u5b66\u526f\u5b66\u9577\uff09<\/p>\n\n\n\n

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\u6587\u732e<\/strong><\/h4>\n\n\n\n
    \n
  1. \u67ff\u5185\u4e09\u90ce (1958\uff09\u554f\u308f\u308c\u308b\u307e\u307e\u306b. \u86cb\u767d\u8cea \u6838\u9178 \u9175\u7d20, 3<\/strong>, 478-481.<\/li>\n\n\n\n
  2. \u5cf6\u8597\u9806\u96c4 (1985) \u67ff\u5185\u4e09\u90ce\u5148\u751f\u4f1d. \u751f\u5316\u5b66, 57<\/strong>, 1501-1502\uff0e<\/li>\n\n\n\n
  3. \u9053\u5bb6\u9054\u5c06 (1964) \u67ff\u5185\u4e09\u90ce\u3068\u65e5\u672c\u306e\u751f\u5316\u5b66. \u81ea\u7136, 19<\/strong>, 110-116\uff0e<\/li>\n\n\n\n
  4. \u4e2d\u5c71\u8302 (1974) \u6b74\u53f2\u3068\u3057\u3066\u306e\u79d1\u5b66, pp.1-302, \u4e2d\u592e\u516c\u8ad6\u793e.<\/li>\n\n\n\n
  5. \u9999\u5ddd\u9756\u96c4 (2015) \u67ff\u5185\u4e09\u90ce\u8a18\u5ff5\u7279\u5225\u8cde\u3092\u53d7\u8cde\u3057\u3066 \u65e5\u672c\u751f\u5316\u5b66\u4f1a\u30fbJB\u306e\u5275\u59cb\u8005. \u751f\u5316\u5b66, 87<\/strong>, 505-509.<\/li>\n\n\n\n
  6. Shimazono, N. (1992) The history of the Japanese Biochemical Society from 1925 to 1990. J. Biochem<\/em>., 122<\/strong>, S3-S18.<\/li>\n\n\n\n
  7. Kakiuchi, S. (1927) The significance of lipoids in the oxygen consuming activity of tissues. 1. The oxygen consuming activity of tissue and the mitochondrial structure. J. Biochem<\/em>. 7<\/strong>, 263\u2013265\uff0e<\/li>\n\n\n\n
  8. Fleischer, S. & Fleischer, B. eds. (1986) Biomembranes, Part N: Transport in Bacteria, Mitochondria, and Chloroplasts: Protonmotive Force. Methods in Enzymology, Vol.126, Academic Press, New York.<\/li>\n\n\n\n
  9. Mitchell P. (1961) Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Nature<\/em> 191<\/strong>, 144-148.<\/li>\n\n\n\n
  10. Kagawa, Y. & Racker, E. (1971) Partial resolution of the enzymes catalyzing oxidative phosphorylation. XXV. Reconstitution of vesicles catalyzing 32<\/sup>Pi-adenosine triphosphate exchange. J. Biol. Chem<\/em>., 246<\/strong>, 5477-5487.<\/li>\n\n\n\n
  11. Kagawa, Y. (2010) ATP synthase: from single molecule to human bioenergetics. Proc. Jpn. Acad., Ser. B<\/em>, 86<\/strong>, 667-693.<\/li>\n\n\n\n
  12. \u9999\u5ddd\u9756\u96c4 (1966) \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u819cATPase\u306e\u518d\u69cb\u6210. \u751f\u5316\u5b66, 38<\/strong>, 719-734.<\/li>\n\n\n\n
  13. \u9999\u5ddd\u9756\u96c4 (1993) \u751f\u547d\u79d1\u5b66\u306e\u696d\u7e3e\u306b\u3088\u308b\u5927\u5b66\u8a55\u4fa1.\u751f\u5316\u5b66, 65<\/strong>, 126-129.<\/li>\n\n\n\n
  14. \u9999\u5ddd\u9756\u96c4 (2021) \u907a\u4f1d\u5b50\u591a\u578b\u306b\u3088\u308b\u30d3\u30bf\u30df\u30f3\u306e\u4e0d\u8db3\u3068\u5bfe\u7b56. \u751f\u5316\u5b66, 93<\/strong>, 109-116.<\/li>\n<\/ol>\n\n\n\n
    <\/div>\n\n\n\n

    \u751f\u5316\u5b66\u4f1a\u5f79\u8077\u6b74<\/h4>\n\n\n\n
      \n
    • 1978\u5e74\u5ea6\u3000\u7406\u4e8b<\/li>\n\n\n\n
    • 1979\u5e74\u5ea6\u3000\u5e38\u52d9\u7406\u4e8b<\/li>\n\n\n\n
    • 1984\u5e74\u5ea6\u3000\u7406\u4e8b<\/li>\n\n\n\n
    • 1985\u5e74\u5ea6\u3000\u5e38\u52d9\u7406\u4e8b<\/li>\n\n\n\n
    • 1989\u5e74\u5ea6\u3000\u5e38\u52d9\u7406\u4e8b<\/li>\n\n\n\n
    • 1989\u5e74\u5ea6\u3000\u5404\u7a2e\u6388\u8cde\u7b49\u9078\u8003\u59d4\u54e1\u4f1a\u59d4\u54e1\u9577<\/li>\n\n\n\n
    • 1990\u5e74\u5ea6\u3000\u5e38\u52d9\u7406\u4e8b<\/li>\n\n\n\n
    • 1994\u5e74\u5ea6\u3000\u5e38\u52d9\u7406\u4e8b<\/li>\n\n\n\n
    • 1995\u5e74\u5ea6\u3000\u526f\u4f1a\u9577<\/li>\n\n\n\n
    • 1995\u5e74\u5ea6\u3000\u5404\u7a2e\u6388\u8cde\u7b49\u9078\u8003\u59d4\u54e1\u4f1a\u59d4\u54e1\u9577<\/li>\n\n\n\n
    • 1998\u5e74\u30fb1999\u5e74\u5ea6\u3000\u76e3\u4e8b<\/li>\n<\/ul>\n\n\n\n

      <\/p>\n","protected":false},"excerpt":{"rendered":"

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