Young Investigator Award

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2011

Hironori Kato
(Kyoto Univ.)
Roles of Rho family GTP ases in neuronal network formation.

Hiromi Hirata
(National Institute of Genetics )
Formation of the nervous system and muscle during motor development.

Kenji Uchimura
(National Center for Geriatrics)
Biological functions and synthesis of carbohydrate sulfation modification.

Masaki Nojiri
(Osaka Univ.)
Structural basis for inter-protein electron transfer in denitrification .

2010

Takeshi Ishimizu
(Osaka Univ.)
Degradation mechanism of plant of N-glycans.

Tetsuya Okajima
(Nagoya Univ.)
Characterization of novel glycosyltransferases involved in the biosynthesis of glycolipids and glycoproteins.

Fumiko Toyoshima
(Kyoto Univ.)
Identification of the novel mechanisms for the control of cell division axis.

Hisaaki Mihara
(Ritsumeikan Univ.)
Discovery and Molecular Function Analysis of Sulfur- and Selenium-eliminating Enzymes Crucial for Biosynthesis of Iron-Sulfur Clusters and Selenoproteins.

2009

Ken Sato
(The Univ. of Tokyo)
Analysis of molecular mechanisms of transport vesicle formation in the ER.

Hideo Shindou
(The Univ. of Tokyo)
Discovery and characterization of novel lysophospholipid acyltransferases.

Toshiki Itoh
(Kobe Univ.)
The mechanism of membrane deformation in endocytosis.

Naotada Ishihara
(Tokyo Medical and Dental Univ.)
Molecular mechanism and physiological roles of mitochondrial fusion and fission.

Satoshi Tanaka
(Mukogawa Women's Univ.)
Molecular analysis of mast cell functions.

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2008

Kohki Kawane
(Kyoto University Graduate School of Medicine)
Analysis of physiological roles of DNases.

Junji Yamauchi
(National Center for Child Medical Health and Development / Tokyo Institute of Technology )
The signal transduction mechanism underlying myelin formation by Schwann cell in peripheral nervous system.

Toshiaki Sakisaka
(Kobe University Graduate School of Medicine)
Vesicle Transport-Dependent Axon Formation.

Ken Sato
(Gunma University Institute for Molecular& Cellular Regulation)
Analysis of ER localization mechanisms of membrane proteins.

Yasuyuki Yamada
(Rikkyo University)
On the regulatory role of the epsilon subunit of ATP synthase.

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2007

Shigeo Murata
(The Tokyo Metropolitan Institute of Medical Science (RINSHOKEN) )
Analysis of regulation of acquired immunity by proteasomes.

Hideki Yamamoto
(Grad.Sch.of Biomedical Sci.,Hiroshima Univ)
Molecular mechanism of the regulation of cellular responses by Wnt signal.

Kiyotsugu Yoshida
(Tokyo Medical and Dental Univ. Medical Research Institute)
Mechanisms for induction of apoptosis in response to DNA damage.

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2006

Masaaki Komatsu
(Juntendo Univ. School of Medicine)
Study on Pathophysiology of Autophagy.

Kazuo Emoto
(National Institute of Genetics)
Studies on phospholipids dynamics and its functions in cytoskeletal organization.

Yoshiteru Hashimoto
(Grad. Sch. of Life and Environmental Sci.,Univ. of Tsukuba )
Disoovery and functional analysis of new enzymes involved in isonitorile and nitrile metabolism.

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2005

Shinobu Kitazume
(Frontier Research System, RIKEN Wako Institute)
Cleavage of a sialyltransferase by Alzheimer's b-secretase.

Akio Kihara
(Grad.Sch.of Pharm.Sci.,Hokkaido Univ)
Elucidation of signaling and dynamics of sphingolipid.

Yukihiko Sugimoto
(Grad.Sch.of Pharm.Sci.,Kyoto Univ)
Structure and function of prostaglandin E receptors and prostaglandin F receptor.

Tadashi Suzuki
(Grad.Sch.of Med.,Osaka Univ)
Studies on structure and biological function of cytoplasmic PNGase.

Masamichi Muramatsu
(Grad.Sch.of Med.,Kyoto Univ)
Isolation of AID and its functional analysis.

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2004

Kazushige Touhara
(Grad. Sch. of Frontier Sci., The Univ.of Tokyo)
Studies on structure and function of olfactory receptors.

Mitsunori Fukuda
(RIKEN Fukuda Initiative Res. Unit)
Roles of synaptotagmin and its related molecules in membrane trafficking.

Ken Itoh
(Tara,/Inst. of Basic Med. Sci.,Univ.of Tsukuba
Protective mechanism against oxidative stress by Keap1/Nrf2 pathway.

Haruhiko Bito
(Grad. Sch. of Med., the Univ.of Tokyo)
Studies on signaling mechanisms regulating plasticity of neuronal morphology.

Shigeru Yanagi
(Kobe Univ. Grad.Sch.of Med.)
Molecular mechanism for semaphorin-mediated signalling.

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2003

Shigehiko Tamura
(Grad. Sch. of Sci., Kyushu Univ.)
A pathogenic gene in an inherited peroxisome disorder and its cellular dysfunction.

Kazutoyo Terada
(Grad. Sch. of Med. Sci., Kumamoto Univ.)
Functional analysis of cytosolic molecular chaperone system

Hiderou Yoshida
(Grad. Sch. of Biostudies, Kyoto Univ./ PRESTO, JST)
Molecular mechanism of mammalian unfolded protein response

Feng Ling
(Cell. & Mol. Biol. Lab., Discovery Res. Inst., RIKEN)
Basic moleclar mechanisms of mitochondrial genetic inheritance

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2002

Hiroshi Kitagawa
(Kobe Pharmaceutical University)
The Tumor Suppressor EXT Gene Family and Biosynthesis of Sulfated Glycosaminoglycans.

Tomomi Gotoh
(Kumamoto University School of Medicine)
Studies on the regulation of NO production and NO-mediated apoptosis.

Kouhei Tsumoto
(Tohoku University,Graduate School of Engineering)
Thermodynamic and Structural Analyses of Specificity and Affinity in Antigen-Antibody Interactions.

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2001

Nobuhisa Iwata
(RIKEN Brain Science Institute)
Identification of the major Ab1-42-degrading catabolic pathway in brain parenchyma.

Hiroaki Miki
(Institute of Medical Science,TheUniversity of Tokyo)
Research on the cytoskeletal reorganization by WASP-family proteins.

Noboru Mizushima
(National Institute for Basic Biology)
Molecular mechanism of autophagy : Role of the Apg12 conjugation system.

Hozumi Motohashi
(Center for TARA,The University of Tsukuba)
Regulatory Mechanism and Functional Contribution of Small Maf Proteins in Vivo.

Takehiko Yokomizo
(The University of Tokyo,Graduate School of Medicine)
Studies on metabolism and receptors of leukotriene B4.

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2000

Tatsuya Sawamura
(National Cardiovascular Center Research Institute)
Discovery and functional analysis of oxidized LDL receptor LOX-1.

Hiroshi Takeshima
(Division of Cell Biology, Institute of Life Science, Kurume University)
Study of Calcium Release from Intracellular Stores.

Makoto Nakanishi
(Department of Biochemistry, Nagoya City University Medical School)
Studies in cell cycle checkpoints and genome stability.

Kentaro Hanada
(National Institute of Infectious Diseases)
Biosynthesis and intracellular transport of sphingolipids in mammalian cells.

Fumihiko Matsuda
(Centre National de Genotypage, Evry FRANCE)
Organization of the human immunoglobulin heavy-chain variable region gene locus.

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1999

Ken-ichi Nishiyama
(Institute of Molecular and Cellular Biosciences, The University of Tokyo)
Molecular mechanisms for preprotein translocation: structure changes of SecA and SecG coupled with translocation.

Hisataka Yasuda
(Research Institute of Life Science, Snow Brand Milk Products)
A Novel Molecular Mechanism Modulating Osteoclast Differentiation and Function.

Hiroyuki Sorimachi
(The University of Tokyo, Graduate School of Agricultural and Life Sciences)
Structure and physiological function of calpain and its homologues.

Keiji Miyazawa
(Tokyo Institute of Technology, Faculty of Biosciences and Biotechnology)
Molecular mechanism regulating activation of hepatocyte growth factor.

Masatsugu Ema
(Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada)
Structure and physiological function of bHLH-PAS transcription factors.

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1998

Kazuhiko Igarashi
(Tohoku University, School of Medicine)
Analysis of transcription factors that bind to the locus control region ofb-globulin gene cluster.

Masato Enari
(Osaka University Medical School)
Signal transduction in Fas-mediated apoptosis.

Hiroshi Shibuya
(National Institute for Basic Biology)
Role of TAK1 and TAB1 in TGF-b signaling.

Hyouta Himeno
(Hirosaki University, Faculty of Agriculture and Life Sciences)
trans-Translation mediated by tmRNA.

Akihiko Yoshimura
(Kurume University, Institute of Life Science)
Signal transduction and regulation of the cytokine receptors.

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1997

Kazuhiro Ogata
(Yokohama City University, School of Medicine)
Structure and dynamics of the transcription factor, Myb, in DNA-sequence recognition.

Kenji Kadomatsu
(Nagoya University, School of Medicine)
Discovery and functional analysis of a heparin-binding growth factor, midkine.

Osamu Kuge
(National Institute of Infectious Diseases)
Genetic and biochemical study on phosphatidylserine biosynthesis in mammalian cells.

Kazutoshi Mori
(HSP Research Institute, Inc.)
Analysis of the unfolded protein response: an intracellular signaling pathway from the endoplasmic reticulum to the nucleus.

Chieko Yokoyama
(National Cardiovascular Center Research Institute)
Molecular biological approaches to cyclooxygenases, thromboxane synthase and prostacyclin synthase in the cyclooxygenase pathway.

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1996

Naoko Imamoto
(Osaka University Medical School)
Molecular mechanism of nuclear protein import.

Shin Takasawa
(Tohoku University School of Medicine)
The cyclic ADP-ribose signal system in insulin secretion.

Kazuma Tanaka
(Osaka University Medical School)
Regulation and modes of action of Ras and Rho small GTP-binding proteins in budding yeast.

Takeshi Tsubata
(Kyoto University, School of Medicine)
Studies on regulatory mechanisms for B lymphocyte apoptosis.

Akiyoshi Fukamizu
(Tsukuba University, Institute of Applied Biochemistry)
Molecular genetics of angiotensin signal transduction system.

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1995

Masato Okada
(Osaka University, Institute for Protein Research)
Role of Csk tyrosin kinase in the regulation of Src family tyrosin kinases.

Akira Kakizuka
(Kyoto University, School of Medicine)
Analysis of dominant mutations and their phenotypes: unraveling of physiological functions of retinoid and identification of the responsible gene for Machado-Joseph disease.

Shun-ichiro Kawabata
(Kyushu University, Faculty of Science)
Structural analysis of defense molecule found in large and small granules in hemocytes of horseshoe crab.

Takaomi Saido
(Tokyo Metropolitan Institute of Medical Science)
Spatial resolution of proteolytic reactions in brain ischemia and Alzheimer's disease.

Masao Sakaguchi
(Kyushu University, School of Medicine)
Characterization of topogenic sequences which regulate integration and membrane topology of proteins in the endoplasmic reticulum membrane.

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1994

Ryuichiro Kageyama
(Kyoto University, School of Medicine)
Regulation of neural differentiation by HES helix-loop-helix transcription factors.

Toshifumi Takao
(Osaka University, Institute for Protein Research)
Analysis of protein primary structures by mass spectrometry.

Kazuhisa Nakayama
(University of Tsukuba, Institute of Biological Sciences)
Studies on processing endoproteases of precursors for biologically active peptides and proteins.

Rikiro Fukunaga
(Osaka Bioscience Institute)
Structure and signal transduction of granulocyte colony-stimulating factor receptor.

Ken-ichirou Morohashi
(Kyushu University School of Medicine)
Structure and regulation of the steroidogenic P450 genes.

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1993

Manabu Negishi
(Kyoto University, Faculty of Pharmaceutical Sciences)
Structure and function of prostaglandin E receptors.

Yoshimi Homma
(Tokyo Metropolitan Institute of Gerontology)
Studies on structure and function of phosphoinositide-specific phospholipase C.

Mitsuo Tagaya
(Osaka University, Institute of Scientific and Industrial Research)
Exploitation of new affinity labeling reagents for nucleotide-binding sites and site-directed mutagenesis.

Masaki Takiguchi
(Kumamoto University School of Medicine)
Regulatory mechanisms of liver-selective transcription of ornithine cycle enzyme genes.

Masamitsu Nakazato
(Miyazaki Medical College)
Biochemical studies of amyloidogenesis in two different types of amyloidoses-amyloid transhyretin variant in familial amyloidotic polyneuropathy and islet amyloid polypeptide in non-insulin-dependent diabetes mellitus.