Young Investigator Award

2017  New!

Kohei Arasaki(School of Life Sciences, Tokyo University of Pharmacy and Life Sciences )

Various functions of ER-localized SNARE protein

 

Eisuke Itakura(Chiba University)

Research of protein quality control system in mammal

 

Yohei Katoh(Kyoto University, Graduate School of Pharmaceutical Sciences )

Molecular basis of intraflagellar transport and ciliopathies

 

Yasuhiko Kizuka(RIKEN ) (*2017.10.1~ Gifu University)

Expression, function and chemical biology of neural glycans

 

Kota Saito(Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo )

Mechanisms of secretion from the ER in higher eukaryotes

 

2016 

Daiju Kitagawa( National Institute of Genetics )

Molecular mechanisms of centriole duplication

 

Mikiko Suzuki( Tohoku Univ.)

Hematopoietic Disorders Driven by Enhancer Abnormality

 

Kazuya Tsujita( Kobe Univ. Biosignal Research Center )

Regulation of membrane tension mediated actin nucleation by membrane bending proteins

 

Yoshikazu Nakamura( Tokyo Univ. of Pharmacy and Life Sciences)

Analysis of physiological functions of phospholipase Cδ

 

Isao Naguro( The Univ. of Tokyo )

Analysis of ASK3 that regulates bidirectional osmotic stress response

 

2015

Ryutaro Asano( Tohoku Univ.)

Study on functional structures of artificial antibodies

 

Umeharu Ohto( The Univ. of Tokyo)

Structural studies of Toll-like receptors in innate immunity

 

Masakazu Sugishima( Kurume Univ.)

Structural study of enzymes involved in heme metabolism

 

Keiko Taguchi( Tohoku Univ.)

Integrated Regulation of Nrf2 by Two Protein Degradation Systems

 

Ayami Matsushima( Kyushu Univ.)

Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptors

 

2014

Hiroshi Nishimasu( The Univ. of Tokyo)

3D view of enzyme functions

 

Jun Suzuki( Kyoto Univ.)

Molecular mechanisms of phospholipid scrambling on plasma membrane

 

Hiroshi Suzuki( The Univ. of Tokyo)

Analysis of microRNA biogenesis and microRNA-mediated gene network regulation

 

Izumi Oinuma( Kyoto Univ.)

Signal transductions of axon guidance factors, semaphorins

 

Yasushi Saeki( Tokyo Metropolitan Institute of Medical Science )

Assembly mechanism and spatio-temporal dynamics of the 26S proteasome

 

2013

Kazuhiro Abe  ( Nagoya Univ.)

Biochemical and electron crystallographic studies of gastric proton pump.

 

Shiro Suetsugu  ( The Univ. of Tokyo)

BAR proteins and the actin cytoskeleton: Cooperative membrane remodeling.

 

Hitoshi Nakatogawa  ( Tokyo Institute of Technology)

Studies on molecular mechanisms underlying autophagy.

 

Keiyo Takubo  ( Keio Univ.)

Elucidation of energy metabolism in hematopoietic stem cells.

 

Motoi Kanagawa  ( Kobe Univ.)

Study on sugar chain function and modification toward understanding muscular dystrophy.

 

2012

Shinji Ihara  (National Institute of Genetics)

Discovery and analysis of the molecules that regulate the process during cell migration and invasion

 

Takumi Koshiba  (Kyushu Univ.)

Molecular mechanism of mitochondrial dynamics and its physiological relevance

 

Takashi Saito  (Riken BSI )

Elucidation of a pathogenic role of Aβ43 in Alzheimer’s disease

 

Nobuo Noda  (Institute of Microbial Chemistry)

Structural biology of autophagy

 

Morihisa Fujita  (Research Institute for Microbial Diseases, Osaka Univ.)

Structural remodeling of GPI-anchors

 

2011

Hironori Kato  (Kyoto Univ.)
Roles of Rho family GTP ases in neuronal network formation

 

Hiromi Hirata  (National Institute of Genetics )
Formation of the nervous system and muscle during motor development

 

Kenji Uchimura  (National Center for Geriatrics)
Biological functions and synthesis of carbohydrate sulfation modification

 

Masaki Nojiri (Osaka Univ.)
Structural basis for inter-protein electron transfer in denitrification

 

2010

Takeshi Ishimizu (Osaka Univ.)
Degradation mechanism of plant of N-glycans

 

Tetsuya Okajima (Nagoya Univ.)
Characterization of novel glycosyltransferases involved in the biosynthesis of glycolipids and glycoproteins

 

Fumiko Toyoshima (Kyoto Univ.)
Identification of the novel mechanisms for the control of cell division axis

 

Hisaaki Mihara (Ritsumeikan Univ.)
Discovery and Molecular Function Analysis of Sulfur- and Selenium-eliminating Enzymes Crucial for Biosynthesis of Iron-Sulfur Clusters and Selenoproteins

 

2009

Ken Sato (The Univ. of Tokyo)
Analysis of molecular mechanisms of transport vesicle formation in the ER

 

Hideo Shindou (The Univ. of Tokyo)
Discovery and characterization of novel lysophospholipid acyltransferases

 

Toshiki Itoh (Kobe Univ.)
The mechanism of membrane deformation in endocytosis

 

Naotada Ishihara (Tokyo Medical and Dental Univ.)
Molecular mechanism and physiological roles of mitochondrial fusion and fission

 

Satoshi Tanaka (Mukogawa Women’s Univ.)
Molecular analysis of mast cell functions

 

2008

Kohki Kawane (Kyoto University Graduate School of Medicine)
Analysis of physiological roles of DNases

 

Junji Yamauchi
(National Center for Child Medical Health and Development / Tokyo Institute of Technology )
The signal transduction mechanism underlying myelin formation by Schwann cell in peripheral nervous system

 

Toshiaki Sakisaka  (Kobe University Graduate School of Medicine)
Vesicle Transport-Dependent Axon Formation

 

Ken Sato  (Gunma University Institute for Molecular& Cellular Regulation)
Analysis of ER localization mechanisms of membrane proteins

 

Yasuyuki Yamada (Rikkyo University)
On the regulatory role of the epsilon subunit of ATP synthase

 

2007

Shigeo Murata (The Tokyo Metropolitan Institute of Medical Science (RINSHOKEN) )
Analysis of regulation of acquired immunity by proteasomes

 

Hideki Yamamoto (Grad.Sch.of Biomedical Sci.,Hiroshima Univ)
Molecular mechanism of the regulation of cellular responses by Wnt signal

 

Kiyotsugu Yoshida  (Tokyo Medical and Dental Univ. Medical Research Institute)
Mechanisms for induction of apoptosis in response to DNA damage

 

2006

Masaaki Komatsu (Juntendo Univ. School of Medicine)
Study on Pathophysiology of Autophagy

 

Kazuo Emoto (National Institute of Genetics)
Studies on phospholipids dynamics and its functions in cytoskeletal organization

 

Yoshiteru Hashimoto  (Grad. Sch. of Life and Environmental Sci.,Univ. of Tsukuba )
Disoovery and functional analysis of new enzymes involved in isonitorile and nitrile metabolism

 

2005

Shinobu Kitazume  (Frontier Research System, RIKEN Wako Institute)
Cleavage of a sialyltransferase by Alzheimer’s b-secretase

 

Akio Kihara  (Grad.Sch.of Pharm.Sci.,Hokkaido Univ)
Elucidation of signaling and dynamics of sphingolipid

 

Yukihiko Sugimoto  (Grad.Sch.of Pharm.Sci.,Kyoto Univ)
Structure and function of prostaglandin E receptors and prostaglandin F receptor

 

Tadashi Suzuki  (Grad.Sch.of Med.,Osaka Univ)
Studies on structure and biological function of cytoplasmic PNGase

 

Masamichi Muramatsu  (Grad.Sch.of Med.,Kyoto Univ)
Isolation of AID and its functional analysis

 

2004

Kazushige Touhara  (Grad. Sch. of Frontier Sci., The Univ.of Tokyo)
Studies on structure and function of olfactory receptors

 

Mitsunori Fukuda  (RIKEN Fukuda Initiative Res. Unit)
Roles of synaptotagmin and its related molecules in membrane trafficking

 

Ken Itoh (Tara,/Inst. of Basic Med. Sci.,Univ.of Tsukuba
Protective mechanism against oxidative stress by Keap1/Nrf2 pathway

 

Haruhiko Bito (Grad. Sch. of Med., the Univ.of Tokyo)
Studies on signaling mechanisms regulating plasticity of neuronal morphology

 

Shigeru Yanagi  (Kobe Univ. Grad.Sch.of Med.)
Molecular mechanism for semaphorin-mediated signalling

 

2003

Shigehiko Tamura (Grad. Sch. of Sci., Kyushu Univ.)
A pathogenic gene in an inherited peroxisome disorder and its cellular dysfunction

 

Kazutoyo Terada (Grad. Sch. of Med. Sci., Kumamoto Univ.)
Functional analysis of cytosolic molecular chaperone system

 

Hiderou Yoshida (Grad. Sch. of Biostudies, Kyoto Univ./ PRESTO, JST)
Molecular mechanism of mammalian unfolded protein response

 

Feng Ling (Cell. & Mol. Biol. Lab., Discovery Res. Inst., RIKEN)
Basic moleclar mechanisms of mitochondrial genetic inheritance

 

2002

Hiroshi Kitagawa (Kobe Pharmaceutical University)
The Tumor Suppressor EXT Gene Family and Biosynthesis of Sulfated Glycosaminoglycans

 

Tomomi Gotoh  (Kumamoto University School of Medicine)
Studies on the regulation of NO production and NO-mediated apoptosis

 

Kouhei Tsumoto (Tohoku University,Graduate School of Engineering)
Thermodynamic and Structural Analyses of Specificity and Affinity in Antigen-Antibody Interactions

 

2001

Nobuhisa Iwata (RIKEN Brain Science Institute)
Identification of the major Ab1-42-degrading catabolic pathway in brain parenchyma

 

Hiroaki Miki (Institute of Medical Science,TheUniversity of Tokyo)
Research on the cytoskeletal reorganization by WASP-family proteins

 

Noboru Mizushima (National Institute for Basic Biology)
Molecular mechanism of autophagy : Role of the Apg12 conjugation system

 

Hozumi Motohashi (Center for TARA,The University of Tsukuba)
Regulatory Mechanism and Functional Contribution of Small Maf Proteins in Vivo

 

Takehiko Yokomizo (The University of Tokyo,Graduate School of Medicine)
Studies on metabolism and receptors of leukotriene B4

 

2000

Tatsuya Sawamura (National Cardiovascular Center Research Institute)
Discovery and functional analysis of oxidized LDL receptor LOX-1

 

Hiroshi Takeshima (Division of Cell Biology, Institute of Life Science, Kurume University)
Study of Calcium Release from Intracellular Stores

 

Makoto Nakanishi (Department of Biochemistry, Nagoya City University Medical School)
Studies in cell cycle checkpoints and genome stability

 

Kentaro Hanada (National Institute of Infectious Diseases)
Biosynthesis and intracellular transport of sphingolipids in mammalian cells

 

Fumihiko Matsuda (Centre National de Genotypage, Evry FRANCE)
Organization of the human immunoglobulin heavy-chain variable region gene locus

 

1999

Ken-ichi Nishiyama
(Institute of Molecular and Cellular Biosciences, The University of Tokyo)
Molecular mechanisms for preprotein translocation: structure changes of SecA and SecG coupled with

translocation

Hisataka Yasuda (Research Institute of Life Science, Snow Brand Milk Products)
A Novel Molecular Mechanism Modulating Osteoclast Differentiation and Function

 

Hiroyuki Sorimachi
(The University of Tokyo, Graduate School of Agricultural and Life Sciences)
Structure and physiological function of calpain and its homologues

 

Keiji Miyazawa
(Tokyo Institute of Technology, Faculty of Biosciences and Biotechnology)
Molecular mechanism regulating activation of hepatocyte growth factor

 

Masatsugu Ema
(Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada)
Structure and physiological function of bHLH-PAS transcription factors

 

1998

Kazuhiko Igarashi (Tohoku University, School of Medicine)
Analysis of transcription factors that bind to the locus control region ofb-globulin gene cluster

 

Masato Enari (Osaka University Medical School)
Signal transduction in Fas-mediated apoptosis

 

Hiroshi Shibuya (National Institute for Basic Biology)
Role of TAK1 and TAB1 in TGF-b signaling

 

Hyouta Himeno (Hirosaki University, Faculty of Agriculture and Life Sciences)
trans-Translation mediated by tmRNA

 

Akihiko Yoshimura (Kurume University, Institute of Life Science)
Signal transduction and regulation of the cytokine receptors

 

1997

Kazuhiro Ogata (Yokohama City University, School of Medicine)
Structure and dynamics of the transcription factor, Myb, in DNA-sequence recognition

 

Kenji Kadomatsu (Nagoya University, School of Medicine)
Discovery and functional analysis of a heparin-binding growth factor, midkine

 

Osamu Kuge (National Institute of Infectious Diseases)
Genetic and biochemical study on phosphatidylserine biosynthesis in mammalian cells

 

Kazutoshi Mori (HSP Research Institute, Inc.)
Analysis of the unfolded protein response: an intracellular signaling pathway from the endoplasmic reticulum to the nucleus

 

Chieko Yokoyama (National Cardiovascular Center Research Institute)
Molecular biological approaches to cyclooxygenases, thromboxane synthase and prostacyclin synthase in the cyclooxygenase pathway

 

1996

Naoko Imamoto (Osaka University Medical School)
Molecular mechanism of nuclear protein import

 

Shin Takasawa (Tohoku University School of Medicine)
The cyclic ADP-ribose signal system in insulin secretion

 

Kazuma Tanaka (Osaka University Medical School)
Regulation and modes of action of Ras and Rho small GTP-binding proteins in budding yeast

 

Takeshi Tsubata(Kyoto University, School of Medicine)
Studies on regulatory mechanisms for B lymphocyte apoptosis

 

Akiyoshi Fukamizu
(Tsukuba University, Institute of Applied Biochemistry)
Molecular genetics of angiotensin signal transduction system

 

1995

Masato Okada (Osaka University, Institute for Protein Research)
Role of Csk tyrosin kinase in the regulation of Src family tyrosin kinases

 

Akira Kakizuka (Kyoto University, School of Medicine)
Analysis of dominant mutations and their phenotypes: unraveling of physiological functions of retinoid and identification of the responsible gene for Machado-Joseph disease

 

Shun-ichiro Kawabata (Kyushu University, Faculty of Science)
Structural analysis of defense molecule found in large and small granules in hemocytes of horseshoe crab

 

Takaomi Saido (Tokyo Metropolitan Institute of Medical Science)
Spatial resolution of proteolytic reactions in brain ischemia and Alzheimer’s disease

 

Masao Sakaguchi (Kyushu University, School of Medicine)
Characterization of topogenic sequences which regulate integration and membrane topology of proteins in the endoplasmic reticulum membrane

 

1994

Ryuichiro Kageyama (Kyoto University, School of Medicine)
Regulation of neural differentiation by HES helix-loop-helix transcription factors

 

Toshifumi Takao (Osaka University, Institute for Protein Research)
Analysis of protein primary structures by mass spectrometry

 

Kazuhisa Nakayama (University of Tsukuba, Institute of Biological Sciences)
Studies on processing endoproteases of precursors for biologically active peptides and proteins

 

Rikiro Fukunaga (Osaka Bioscience Institute)
Structure and signal transduction of granulocyte colony-stimulating factor receptor

 

Ken-ichirou Morohashi (Kyushu University School of Medicine)
Structure and regulation of the steroidogenic P450 genes

 

1993

Manabu Negishi (Kyoto University, Faculty of Pharmaceutical Sciences)
Structure and function of prostaglandin E receptors

 

Yoshimi Homma (Tokyo Metropolitan Institute of Gerontology)
Studies on structure and function of phosphoinositide-specific phospholipase C

 

Mitsuo Tagaya
(Osaka University, Institute of Scientific and Industrial Research)
Exploitation of new affinity labeling reagents for nucleotide-binding sites and site-directed mutagenesis

 

Masaki Takiguchi (Kumamoto University School of Medicine)
Regulatory mechanisms of liver-selective transcription of ornithine cycle enzyme genes

 

Masamitsu Nakazato (Miyazaki Medical College)
Biochemical studies of amyloidogenesis in two different types of amyloidoses-amyloid transhyretin variant in familial amyloidotic polyneuropathy and islet amyloid polypeptide in non-insulin-dependent diabetes mellitus