Young Investigator Award

2021  New!

Hiroaki Tachiwana (Japanese Foundation For Cancer Research)

Analysis of chromatin structure and function formed by histone variants


Hideaki Morishita (Juntendo University Graduate School of Medicine)

Discovery of a macroautophagy-independent mechanism for largescale organelle degradation in vertebrate lens


Yusuke Sato (Faculty of Engineering, Tottori University)

Structural biology of the ubiquitin signal 


Shun Nagashima (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences)

Elucidating the role of mitochondria-organelle contacts


Naoe Taira Nihira (Medical Research Institute, Tokyo Medical and Dental University)

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy 



Keisuke Yanagita (Department of  Liquid Signaling, National Center for Global Health and Medicine)

Lysophospholipid mediators in physiology and pathology


Shinji Matsumoto (Graduate School of Medicine, Osaka University)

Epithelial morphogenesis and implication in tumorigenesis due to its abnormality.


Satoshi Ninagawa (Graduate School of Science, Kyoto University)

Analysis of endoplasmic reticulum-associated degradation using gene knockouts


Kenta Moriwaki (Faculty of Medicine, Toho University)

Regulatory mechanisms of death receptor signaling and its pathological functions


Taro Chaya (Institute for Protein Research, Osaka University)

Elucidation of the mechanism and physiological significance of protein transport in cilia 



Tomoya Kujirai (Institute for Quantitative Biosciences, The University of Tokyo)

Structural Basis of transcription on chromatin structure


Ryo Ushioda (Faculty of Life Sciences, Kyoto Sangyo University)

Maintenance of ER homeostasis through Redox regulation


Toshio Shibata (Graduate School of science, Kyushu University)

Functional analysis and secretion mechanism of Drosophila transglutaminase


Hiroyuki Terashima (Graduate School of science, Nagoya University)

Molecular mechanism of nano-scale rotary machine, bacterial flagellar motor.


Yusuke Kishi (Graduate School of  pharmaceutical Sciences, The University of Tokyo)

Chromatin regulation of neurogenic potential in neural stem cells 



Katsumori Segawa(Immunology Frontier Research Center, Osaka University )

Mechanisms for phospholipid translocation and recognition of dead cells


Reiko Satow (Tokyo Univ. of Pharmacy and Life Sciences)

Molecular Mechanisms of Drug Resistance in Cancer Cells


Hikari Yoshitane (The University of Tokyo)

Posttranscriptional and posttranslational regulation in mammalian circadian clockwork


Hirokazu Yagi(Nagoya City University, Graduate School of Pharmaceutical Sciences)

Molecular mechanisms underlying the protein-specificity of glycosylation


Koji Yamano (Tokyo Metropolitan Institute of Medical Science)

Study for selective degradation of damaged mitochondria



Kohei Arasaki(School of Life Sciences, Tokyo University of Pharmacy and Life Sciences )

Various functions of ER-localized SNARE protein


Eisuke Itakura(Chiba University)

Research of protein quality control system in mammal


Yohei Katoh(Kyoto University, Graduate School of Pharmaceutical Sciences )

Molecular basis of intraflagellar transport and ciliopathies


Yasuhiko Kizuka(RIKEN ) (*2017.10.1~ Gifu University)

Expression, function and chemical biology of neural glycans


Kota Saito(Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo )

Mechanisms of secretion from the ER in higher eukaryotes



Daiju Kitagawa( National Institute of Genetics )

Molecular mechanisms of centriole duplication


Mikiko Suzuki( Tohoku Univ.)

Hematopoietic Disorders Driven by Enhancer Abnormality


Kazuya Tsujita( Kobe Univ. Biosignal Research Center )

Regulation of membrane tension mediated actin nucleation by membrane bending proteins


Yoshikazu Nakamura( Tokyo Univ. of Pharmacy and Life Sciences)

Analysis of physiological functions of phospholipase Cδ


Isao Naguro( The Univ. of Tokyo )

Analysis of ASK3 that regulates bidirectional osmotic stress response



Ryutaro Asano( Tohoku Univ.)

Study on functional structures of artificial antibodies


Umeharu Ohto( The Univ. of Tokyo)

Structural studies of Toll-like receptors in innate immunity


Masakazu Sugishima( Kurume Univ.)

Structural study of enzymes involved in heme metabolism


Keiko Taguchi( Tohoku Univ.)

Integrated Regulation of Nrf2 by Two Protein Degradation Systems


Ayami Matsushima( Kyushu Univ.)

Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptors



Hiroshi Nishimasu( The Univ. of Tokyo)

3D view of enzyme functions


Jun Suzuki( Kyoto Univ.)

Molecular mechanisms of phospholipid scrambling on plasma membrane


Hiroshi Suzuki( The Univ. of Tokyo)

Analysis of microRNA biogenesis and microRNA-mediated gene network regulation


Izumi Oinuma( Kyoto Univ.)

Signal transductions of axon guidance factors, semaphorins


Yasushi Saeki( Tokyo Metropolitan Institute of Medical Science )

Assembly mechanism and spatio-temporal dynamics of the 26S proteasome



Kazuhiro Abe  ( Nagoya Univ.)

Biochemical and electron crystallographic studies of gastric proton pump.


Shiro Suetsugu  ( The Univ. of Tokyo)

BAR proteins and the actin cytoskeleton: Cooperative membrane remodeling.


Hitoshi Nakatogawa  ( Tokyo Institute of Technology)

Studies on molecular mechanisms underlying autophagy.


Keiyo Takubo  ( Keio Univ.)

Elucidation of energy metabolism in hematopoietic stem cells.


Motoi Kanagawa  ( Kobe Univ.)

Study on sugar chain function and modification toward understanding muscular dystrophy.



Shinji Ihara  (National Institute of Genetics)

Discovery and analysis of the molecules that regulate the process during cell migration and invasion


Takumi Koshiba  (Kyushu Univ.)

Molecular mechanism of mitochondrial dynamics and its physiological relevance


Takashi Saito  (Riken BSI )

Elucidation of a pathogenic role of Aβ43 in Alzheimer’s disease


Nobuo Noda  (Institute of Microbial Chemistry)

Structural biology of autophagy


Morihisa Fujita  (Research Institute for Microbial Diseases, Osaka Univ.)

Structural remodeling of GPI-anchors



Hironori Kato  (Kyoto Univ.)
Roles of Rho family GTP ases in neuronal network formation


Hiromi Hirata  (National Institute of Genetics )
Formation of the nervous system and muscle during motor development


Kenji Uchimura  (National Center for Geriatrics)
Biological functions and synthesis of carbohydrate sulfation modification


Masaki Nojiri (Osaka Univ.)
Structural basis for inter-protein electron transfer in denitrification



Takeshi Ishimizu (Osaka Univ.)
Degradation mechanism of plant of N-glycans


Tetsuya Okajima (Nagoya Univ.)
Characterization of novel glycosyltransferases involved in the biosynthesis of glycolipids and glycoproteins


Fumiko Toyoshima (Kyoto Univ.)
Identification of the novel mechanisms for the control of cell division axis


Hisaaki Mihara (Ritsumeikan Univ.)
Discovery and Molecular Function Analysis of Sulfur- and Selenium-eliminating Enzymes Crucial for Biosynthesis of Iron-Sulfur Clusters and Selenoproteins



Ken Sato (The Univ. of Tokyo)
Analysis of molecular mechanisms of transport vesicle formation in the ER


Hideo Shindou (The Univ. of Tokyo)
Discovery and characterization of novel lysophospholipid acyltransferases


Toshiki Itoh (Kobe Univ.)
The mechanism of membrane deformation in endocytosis


Naotada Ishihara (Tokyo Medical and Dental Univ.)
Molecular mechanism and physiological roles of mitochondrial fusion and fission


Satoshi Tanaka (Mukogawa Women’s Univ.)
Molecular analysis of mast cell functions



Kohki Kawane (Kyoto University Graduate School of Medicine)
Analysis of physiological roles of DNases


Junji Yamauchi
(National Center for Child Medical Health and Development / Tokyo Institute of Technology )
The signal transduction mechanism underlying myelin formation by Schwann cell in peripheral nervous system


Toshiaki Sakisaka  (Kobe University Graduate School of Medicine)
Vesicle Transport-Dependent Axon Formation


Ken Sato  (Gunma University Institute for Molecular& Cellular Regulation)
Analysis of ER localization mechanisms of membrane proteins


Yasuyuki Yamada (Rikkyo University)
On the regulatory role of the epsilon subunit of ATP synthase



Shigeo Murata (The Tokyo Metropolitan Institute of Medical Science (RINSHOKEN) )
Analysis of regulation of acquired immunity by proteasomes


Hideki Yamamoto (Grad.Sch.of Biomedical Sci.,Hiroshima Univ)
Molecular mechanism of the regulation of cellular responses by Wnt signal


Kiyotsugu Yoshida  (Tokyo Medical and Dental Univ. Medical Research Institute)
Mechanisms for induction of apoptosis in response to DNA damage



Masaaki Komatsu (Juntendo Univ. School of Medicine)
Study on Pathophysiology of Autophagy


Kazuo Emoto (National Institute of Genetics)
Studies on phospholipids dynamics and its functions in cytoskeletal organization


Yoshiteru Hashimoto  (Grad. Sch. of Life and Environmental Sci.,Univ. of Tsukuba )
Disoovery and functional analysis of new enzymes involved in isonitorile and nitrile metabolism



Shinobu Kitazume  (Frontier Research System, RIKEN Wako Institute)
Cleavage of a sialyltransferase by Alzheimer’s b-secretase


Akio Kihara  (Grad.Sch.of Pharm.Sci.,Hokkaido Univ)
Elucidation of signaling and dynamics of sphingolipid


Yukihiko Sugimoto  (Grad.Sch.of Pharm.Sci.,Kyoto Univ)
Structure and function of prostaglandin E receptors and prostaglandin F receptor


Tadashi Suzuki  (Grad.Sch.of Med.,Osaka Univ)
Studies on structure and biological function of cytoplasmic PNGase


Masamichi Muramatsu  (Grad.Sch.of Med.,Kyoto Univ)
Isolation of AID and its functional analysis



Kazushige Touhara  (Grad. Sch. of Frontier Sci., The Univ.of Tokyo)
Studies on structure and function of olfactory receptors


Mitsunori Fukuda  (RIKEN Fukuda Initiative Res. Unit)
Roles of synaptotagmin and its related molecules in membrane trafficking


Ken Itoh (Tara,/Inst. of Basic Med. Sci.,Univ.of Tsukuba
Protective mechanism against oxidative stress by Keap1/Nrf2 pathway


Haruhiko Bito (Grad. Sch. of Med., the Univ.of Tokyo)
Studies on signaling mechanisms regulating plasticity of neuronal morphology


Shigeru Yanagi  (Kobe Univ. Grad.Sch.of Med.)
Molecular mechanism for semaphorin-mediated signalling



Shigehiko Tamura (Grad. Sch. of Sci., Kyushu Univ.)
A pathogenic gene in an inherited peroxisome disorder and its cellular dysfunction


Kazutoyo Terada (Grad. Sch. of Med. Sci., Kumamoto Univ.)
Functional analysis of cytosolic molecular chaperone system


Hiderou Yoshida (Grad. Sch. of Biostudies, Kyoto Univ./ PRESTO, JST)
Molecular mechanism of mammalian unfolded protein response


Feng Ling (Cell. & Mol. Biol. Lab., Discovery Res. Inst., RIKEN)
Basic moleclar mechanisms of mitochondrial genetic inheritance



Hiroshi Kitagawa (Kobe Pharmaceutical University)
The Tumor Suppressor EXT Gene Family and Biosynthesis of Sulfated Glycosaminoglycans


Tomomi Gotoh  (Kumamoto University School of Medicine)
Studies on the regulation of NO production and NO-mediated apoptosis


Kouhei Tsumoto (Tohoku University,Graduate School of Engineering)
Thermodynamic and Structural Analyses of Specificity and Affinity in Antigen-Antibody Interactions



Nobuhisa Iwata (RIKEN Brain Science Institute)
Identification of the major Ab1-42-degrading catabolic pathway in brain parenchyma


Hiroaki Miki (Institute of Medical Science,TheUniversity of Tokyo)
Research on the cytoskeletal reorganization by WASP-family proteins


Noboru Mizushima (National Institute for Basic Biology)
Molecular mechanism of autophagy : Role of the Apg12 conjugation system


Hozumi Motohashi (Center for TARA,The University of Tsukuba)
Regulatory Mechanism and Functional Contribution of Small Maf Proteins in Vivo


Takehiko Yokomizo (The University of Tokyo,Graduate School of Medicine)
Studies on metabolism and receptors of leukotriene B4



Tatsuya Sawamura (National Cardiovascular Center Research Institute)
Discovery and functional analysis of oxidized LDL receptor LOX-1


Hiroshi Takeshima (Division of Cell Biology, Institute of Life Science, Kurume University)
Study of Calcium Release from Intracellular Stores


Makoto Nakanishi (Department of Biochemistry, Nagoya City University Medical School)
Studies in cell cycle checkpoints and genome stability


Kentaro Hanada (National Institute of Infectious Diseases)
Biosynthesis and intracellular transport of sphingolipids in mammalian cells


Fumihiko Matsuda (Centre National de Genotypage, Evry FRANCE)
Organization of the human immunoglobulin heavy-chain variable region gene locus



Ken-ichi Nishiyama
(Institute of Molecular and Cellular Biosciences, The University of Tokyo)
Molecular mechanisms for preprotein translocation: structure changes of SecA and SecG coupled with


Hisataka Yasuda (Research Institute of Life Science, Snow Brand Milk Products)
A Novel Molecular Mechanism Modulating Osteoclast Differentiation and Function


Hiroyuki Sorimachi
(The University of Tokyo, Graduate School of Agricultural and Life Sciences)
Structure and physiological function of calpain and its homologues


Keiji Miyazawa
(Tokyo Institute of Technology, Faculty of Biosciences and Biotechnology)
Molecular mechanism regulating activation of hepatocyte growth factor


Masatsugu Ema
(Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada)
Structure and physiological function of bHLH-PAS transcription factors



Kazuhiko Igarashi (Tohoku University, School of Medicine)
Analysis of transcription factors that bind to the locus control region ofb-globulin gene cluster


Masato Enari (Osaka University Medical School)
Signal transduction in Fas-mediated apoptosis


Hiroshi Shibuya (National Institute for Basic Biology)
Role of TAK1 and TAB1 in TGF-b signaling


Hyouta Himeno (Hirosaki University, Faculty of Agriculture and Life Sciences)
trans-Translation mediated by tmRNA


Akihiko Yoshimura (Kurume University, Institute of Life Science)
Signal transduction and regulation of the cytokine receptors



Kazuhiro Ogata (Yokohama City University, School of Medicine)
Structure and dynamics of the transcription factor, Myb, in DNA-sequence recognition


Kenji Kadomatsu (Nagoya University, School of Medicine)
Discovery and functional analysis of a heparin-binding growth factor, midkine


Osamu Kuge (National Institute of Infectious Diseases)
Genetic and biochemical study on phosphatidylserine biosynthesis in mammalian cells


Kazutoshi Mori (HSP Research Institute, Inc.)
Analysis of the unfolded protein response: an intracellular signaling pathway from the endoplasmic reticulum to the nucleus


Chieko Yokoyama (National Cardiovascular Center Research Institute)
Molecular biological approaches to cyclooxygenases, thromboxane synthase and prostacyclin synthase in the cyclooxygenase pathway



Naoko Imamoto (Osaka University Medical School)
Molecular mechanism of nuclear protein import


Shin Takasawa (Tohoku University School of Medicine)
The cyclic ADP-ribose signal system in insulin secretion


Kazuma Tanaka (Osaka University Medical School)
Regulation and modes of action of Ras and Rho small GTP-binding proteins in budding yeast


Takeshi Tsubata(Kyoto University, School of Medicine)
Studies on regulatory mechanisms for B lymphocyte apoptosis


Akiyoshi Fukamizu
(Tsukuba University, Institute of Applied Biochemistry)
Molecular genetics of angiotensin signal transduction system



Masato Okada (Osaka University, Institute for Protein Research)
Role of Csk tyrosin kinase in the regulation of Src family tyrosin kinases


Akira Kakizuka (Kyoto University, School of Medicine)
Analysis of dominant mutations and their phenotypes: unraveling of physiological functions of retinoid and identification of the responsible gene for Machado-Joseph disease


Shun-ichiro Kawabata (Kyushu University, Faculty of Science)
Structural analysis of defense molecule found in large and small granules in hemocytes of horseshoe crab


Takaomi Saido (Tokyo Metropolitan Institute of Medical Science)
Spatial resolution of proteolytic reactions in brain ischemia and Alzheimer’s disease


Masao Sakaguchi (Kyushu University, School of Medicine)
Characterization of topogenic sequences which regulate integration and membrane topology of proteins in the endoplasmic reticulum membrane



Ryuichiro Kageyama (Kyoto University, School of Medicine)
Regulation of neural differentiation by HES helix-loop-helix transcription factors


Toshifumi Takao (Osaka University, Institute for Protein Research)
Analysis of protein primary structures by mass spectrometry


Kazuhisa Nakayama (University of Tsukuba, Institute of Biological Sciences)
Studies on processing endoproteases of precursors for biologically active peptides and proteins


Rikiro Fukunaga (Osaka Bioscience Institute)
Structure and signal transduction of granulocyte colony-stimulating factor receptor


Ken-ichirou Morohashi (Kyushu University School of Medicine)
Structure and regulation of the steroidogenic P450 genes



Manabu Negishi (Kyoto University, Faculty of Pharmaceutical Sciences)
Structure and function of prostaglandin E receptors


Yoshimi Homma (Tokyo Metropolitan Institute of Gerontology)
Studies on structure and function of phosphoinositide-specific phospholipase C


Mitsuo Tagaya
(Osaka University, Institute of Scientific and Industrial Research)
Exploitation of new affinity labeling reagents for nucleotide-binding sites and site-directed mutagenesis


Masaki Takiguchi (Kumamoto University School of Medicine)
Regulatory mechanisms of liver-selective transcription of ornithine cycle enzyme genes


Masamitsu Nakazato (Miyazaki Medical College)
Biochemical studies of amyloidogenesis in two different types of amyloidoses-amyloid transhyretin variant in familial amyloidotic polyneuropathy and islet amyloid polypeptide in non-insulin-dependent diabetes mellitus